Conference Program

PRE-CONFERENCE WORKSHOPS
Thursday, November 17, 2016
13:00-17:00
 A.
13:00-14:45
In vitro follicle/oocyte maturation age : From primordial stages

B.
13:00-14:45
A new paradigm in clinical IVF: Age-specific stimulation and embryology

 14:15-15:15 Coffee Break
 C.
15:15-17:00
An in vitro implantation model: Peeking into the "black box" of implantation

 D.
15:15-17:00
The biological basis for the demise of preimplantation genetic screening (PGS)

   
Day 1
Friday, November 18, 2016

08:30-12:45
 PLENARY SESSION
08:30-08:45 Welcome and announcement of the "Young Investigator Awards"
Norbert Gleicher, USA and Zeev Shoham, Israel
08:45-09:15
  
The "Breaking News" Lecture
Building the mouse and human embryo: Cell fate and plasticity
Magdalena Zernicka-Goetz, UK
   
09:15-11:15          
PART I: THE FUTURE OF FERTILITY CARE
Chairs: Norbert Gleicher, USA and Ali H. Brivanlou, USA
09:15-09:45
 
From stem cells to oocytes and sperm
Ali H. Brivanlou, USA
09:45-10:15
 
Preventing mitrochondrial diseases with 3-parent IVF?
Hong Ma, USA
10:15-10:45
 
Eliminating mitochondrial diseases in embryos
Juan Carlos Izpisua Belmonte, USA
10:45-11:15
 
  
Ethical considerations on crossing the germline
Arthur L. Caplan, USA
  
11:15-11:45 Coffee Break & Poster Viewing
11:45-12:45 PART II: THE FUTURE OF FERTILITY CARE continued
Chairs: Juan Carlos Izpisua Belmonte, USA and Zeev Shoham, Israel
11:45-12:15
 
Can we learn to in vitro mature primordial follicles?
Evelyn Telfer, UK
12:15-12:45
 
  
Shining some light into the black box of implantation
Gist Croft, USA
  
12:45-13:15
Get your lunch "to-go"
LUNCH BREAK DEBATE - bring your lunch

13:15-14:15
Chair: Eli Y, Adashi, USA
Ovarian stem cells: Should we be considering and preparing for Clinical application?
It's Premature: David F. Albertini, USA
The time is now: Evelyn Telfer, UK

14:15-14:30
Technical Break
14:30-17:15
PARADIGM CHANGE I: EXPANDING INFERTILITY TREATMENTS FROM THE GONADOTROPIN-SENSITIVE TO EARLIER STAGES OF FOLLICLE MATURATION
14:30-16:00
PART I: IMPORTANCE OF ANDROGENS
Chairs:
David F. Albertini, USA and Eli Y. Adashi, USA
14:30-15:00

Animal models demonstrating the importance of androgens for early stages of follicle maturation
Aritro Sen, USA
15:00-15:30


Androgen supplementation, a model for therapeutic interventions into early stages of follicle maturation in humans
Norbert Gleicher, USA
15:30-16:00
  

The potential diagnostic importance of conversion dynamics of DHEA to testosterone
Aya Shohat-Tal, USA
  
16:00-16:30
Coffee Break & Poster Viewing
16:30-17:15
PART II: CLINICAL RELEVANCE AND PRACTICAL ADVICE
Chairs:
Milton Leong, Hong Kong/Canada and Andrea Weghofer, Austria
16:30-16:45

Are we intervening too late with embryo selection?
David F. Albertini, USA
16:45-17:00

Is human growth hormone effective in improving ovarian stimulation?
David H. Barad, USA
17:00-17:15
 


How introduction of unproven new treatment modifications to IVF has negatively affected treatment outcomes around the world
Vitaly A. Kushnir, USA
  
Day 2
Saturday, November 19, 2016

  PARADIGM CHANGE I: EXPANDING INFERTILITY TREATMENTS FROM THE GONADOTROPIN-SENSITIVE TO EARLIER STAGES OF FOLLICLE MATURATION continued ...
08:30-11:00
PART III: CAN WE LEARN TO CLINICALLY CONTROL FOLLICLE RECRUITMENT?
Chairs:
Aritro Sen, USA and David B. Seifer, USA
08:30-09:00

Genetic control of follicle recruitment
Aleksandar Rajkovic, USA
09:00-09:30

The FMRI gene in human reproduction
Aya Shohat-Tal, USA
09:30-10:00

Physiology and clinical utility of AMH in follicle recruitment and growth
David B. Seifer, USA
10:00-10:30

Piercing out AMH's ovarian function in small animal models
Aritro Sen, USA
10:30-11:00
 
Pharmacological control of follicle recruitment?
Kara N. Goldman, USA
 
11:00-11:30
Coffee Break and Poster Viewing
11:30-13:00
 
PARADIGM CHANGE II: EARLY DIAGNOSIS OF PREMATURE OVARIAN SENESCENCE, OFFERING WOMEN MORE AND BETTER REPRODUCTIVE OPTIONS
Chairs:
Aleksandar Rajkovic, USA and Kara N. Goldman, USA
11:30-12:00

Risk-screening algorithm for young women to detect premature ovarian senescence at younger ages
Vitaly A. Kushnir, USA
12:00-12:30

A candid assessment of social fertility preservation via oocyte cryopreservation
Pasquale Patrizio, USA
12:30-13:00
 
Fertility preservation in young cancer patients
Vitaly A. Kushnir, USA
  
13:00-13:30
Get your lunch "to-go"
LUNCH BREAK DEBATE - bring your lunch

13:30-14:30
Chair: Raoul Orvieto, Israel
Are twins an adverse IVF outcome?
YES:
The majority view on multiple births in the modern era of fertility promotion
Eli Y. Adashi
, USA
NO: The single embryo transfer myth
Norbert Gleicher
, USA

14:30-14:45 Technical Break
14:45-16:15
PARADIGM CHANGE III: RECONSIDERING EMBRYO SELECTION
Chair: Pasquale Patrizio, USA
14:45-15:15

As practiced today, embryo selection, marginally benefits few - while potentially harming many
Norbert Gleicher, USA
15:15-15:45

A critical review of routine utilization of PGS in IVF
David H. Barad, USA
15:45-16:15
 

Reviewing routine clinical utilization of closed incubation systems with time lapse photography
Catherine Racowsky, USA
 
16:15-16:45
Coffee Break and Poster Viewing
16:45-17:45
PARADIGM CHANGE IV: INDIVIDUALIZATION OF INFERTILITY CARE
Chairs:
Catherine Racowsky, USA and David H. Barad, USA
16:45-17:15
Individualization of ovarian stimulation protocols
Raoul Orvieto, Israel
17:15-17:45
 


Premature luteinization of follicles and indication for individualization of timing hCG administration based on "ovarian age"
Yan-Guang Wu, USA 
 
Day 3
Sunday, November 20, 2106

09:00-13:10 SCEPTICAL OF CURRENT CLINICAL PRACTICES? HERE ARE SOME ANSWERS!
09:00-11:00
PART I
Chairs:
David F. Albertini, USA and Andrea Weghofer, Austria
09:00-09:20

What constitutes "futile" fertility treatments?  Are we pushing patients too early into egg donations?
David H. Barad, USA
09:20-09:40

Are frozen eggs really equivalent to fresh donor eggs?
Vitaly A. Kushnir, USA
09:40-10:00

The controversy about the relative relevance of thyroid-function and thyroid autoimmunity for IVF success?
Andrea Weghofer, Austria
10:00-10:20

Is the immune system (i.e. autoimmunity and inflammation) really irrelevant to IVF success - as suggested by some?
Norbert Gleicher, USA
10:20-10:40

Access to infertility care in the US: The realities of the public and private sectors
Eli Y. Adashi, USA
10:40-11:00
 
 
Does it matter how we stimulate the poor responder with low functional ovarian reserve?
Raoul Orvieto, Israel
 
11:00-11:30 Coffee Break 
11:30-13:10
PART II
Chairs:
Yan-Guang Wu, USA and Vitaly A. Kushnir, USA
11:30-11:50

Does ICSI really increase autism risks?
David H. Barad, USA
11:50-12:10
 
Does embryo aneuploidy really significantly increase with gonadotropin dosages?
Andrea Weghofer, Austria
12:10-12:30
 
Immunological pregnancy loss
Norbert Gleicher, USA
12:30-12:50

The myths of mild stimulation and natural cycle IVF
Raoul Orvieto, USA
12:50-13:10

What is the real evidence that endometrial injury improves IVF outcomes?
Zeev Shoham, Israel
13:10
 

CLOSING REMARKS
Norbert Gleicher
, USA